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October 2017 • The PCB Design Magazine 35 5. Polar Instruments Si9000e Version 2017. 6. Keysight Advanced Design System (ADS) Version 2016. 7. Park Electrochemical Corp. Nelco Digital Electronic Materials. 8. Oak-Mitsui. Bert Simonovich is the founder of Lamsim Enterprises, where he provides innovative signal integrity and backplane solutions to clients. His current research interests in- clude signal integrity, high-speed characterization, and modeling of high-speed serial links associated with backplane interconnects. To contact him or read past col- umns, click here. good answer later, then this method might be right for you. PCBDESIGN References 1. Bert Simonovich, "A Practical Method to Model Effective Permittivity and Phase Delay Due to Conductor Surface Roughness," DesignCon 2017 Proceedings, Santa Clara, California, 2017. 2. Bert Simonovich, "Practical Model of Conductor Surface Roughness Using Cubic Close-packing of Equal Spheres," EDICon 2016, Boston, Massachusetts. 3. Hammerstad, E.; Jensen, O., "Accurate Models for Microstrip Computer-Aided Design," Microwave Symposium Digest, 1980 IEEE MTT- S International, pp.407,409, 28-30 May 1980 doi: 10.1109/MWSYM.1980.1124303. 4. Huray, P. G. (2009) "The Foundations of Signal Integrity," John Wiley & Sons Inc., Hobo- ken, NJ, USA., 2009. PRACTICAL MODELING OF HIGH-SPEED BACKPLANE CHANNELS Research being done at Rochester Institute of Technology to refine lab-on-chip devices will pro- vide more detailed and timely information to de- tect diseases such as cancer. Blanca Lapizco-Encinas, a faculty-researcher in RIT's Kate Gleason College of Engineering, is im- proving the process of separating biological cells and biomolecules using chromatography prin- ciples, a well-established technique for separating proteins, combined with a newer technique called dielectrophoresis, a process that uses electrical cur- rent to separate biomolecules. In biomedical analysis, clinicians may have to analyze complex blood samples consisting of cells, proteins and other micron-sized particles, in an effort to separate healthy and diseased cells. Im- proved microfluidic techniques with the potential to separate cells found in bio-fluids, are use- ful in settings where rapid results are essential such as testing for food and water safety or clinical analysis of disease. "You put into a device a sample with six or sev- en different types of particles and you can separate them, in some cases in less than two minutes, just by applying electric fields," Lapizco-Encinas ex- plained. The new research, utilizing electroosmotic flow is expected to drive particles across the micro- channel. This process of electroosmotic flow offers the potential for the biomolecules to be manipu- lated in real-time, allowing for dynamic separation schemes. This work expands Lapizco-Encinas' pre- vious research that focused on the development of multi-channel devices where fluid samples are as- sessed after being exposed to electrical currents that cause the bio-particles to separate for more efficient analysis. Through past research, she and her team advanced device system designs and determined an optimal threshold of electrical fields applied to adequately manipulate the fluids and ensure that live cells are not damaged. Adding chromatographic principles to this foundational work is underway. Hybrid Biological Cell Separations Technology for Lab-On-Chip Medical Devices

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